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Gender assignment in patients with genital ambiguity should be made only after careful investigation by a multidisciplinary team; increasingly, surgical decisions are delayed until the child is able to participate in the decision-making process.
Ovotesticular disorder is defined by the presence of both ovarian follicles and seminiferous tubules in the same patient. Lin YT, Capel B. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form.
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Paradoxically, male infants with HSD3B2 and POR mutations may present with undervirilization due atypical sex differentiation in language in Nanaimo impaired testosterone biosynthesis [ 19 ]. Subscribe to Pediatric Care Online Purchase your individual subscription.
Author manuscript; available in PMC Apr 1. If the affected child is female, the high androgen levels before birth cause the genitals to become more male in appearance. What are the types of disorders of sex differentiation DSD? Developmental Biology.
Estrogen and progesterone hormone therapy are essential to promote development of secondary sexual characteristics and prevent osteopenia [ 34 ].
You will be redirected to aap. Physical findings in patients with DSD may range from an apparently normal phenotype to complete ambiguity. We do not endorse non-Cleveland Clinic products or services. The testes usually remain inside the body and the womb does not develop.
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