The uterus weight at termination can be used to ensure that the appropriate age in the immature intact rat was not exceeded, however, the historical data of the rat strain used by the laboratory are decisive in this respect see paragraph 56 for interpretation of the results.
Danish Environmental Protection Agency Neurotoxicology. The choice of a parametric or a nonparametric analysis should be justified by considering factors such as the nature of the data transformed or not and their distribution, as well as the relative robustness of the statistical analysis selected.
Introduction to Statistics Textbook. Test chemical : Any substance or mixture tested using this test method. The rat has been routinely used in the Hershberger Bioassay since the s. Any losses, leakage at the injection site or incomplete dosing should be recorded.
Baseline Positive Control Study — Before a laboratory conducts a study under this test method for the first time, laboratory proficiency should be demonstrated by testing the responsiveness of the animal model, by establishing the dose response of a reference oestrogen: 17a-ethinyl estradiol CAS No EE with a minimum of four doses.
Try it risk-free for 30 days. Any alterations in pup assignments should be reported. The highest dose should represent the maximum tolerated dose MTD ; a study conducted at a dose level that induced a positive uterotrophic response would be accepted too.
As an optional measurement, the amount of food consumed during the treatment period may be measured per cage by weighing the feeders. Experimental control involves producing small variations in body weight within and among the study groups. We will also be talking about two other types of measuring data: interval and ratio measurements.
This one's not as easy to compare as was. Neuropathological evaluation should include an examination for indications of developmental damage to the nervous system 6 85 86 87 88 89 , in addition to the cellular alterations e.