In addition, a body of evidence either from in vitro studies using testicular-derived mesenchymal cells in culture or from in vivo studies using the Tfm mice have demonstrated that the development of adult Leydig cell function definitely requires the action of androgens 88 Meistrich, M.
Leak, Lymph vascular system of the interstitial tissue of the testis as revealed by electron microscopy. Mori, Aono, T.
The lack of functional AR in Leydig cells has a major influence on Leydig cells steroidogenic functions leading to spermatogenesis arrest predominately at the round spermatid stage Science, Several studies indicated that AR is present in germ cells in different species 323435363738394041but other reports show that there is no AR staining in the germ cells 303342434445 Google Scholar.
In contrast, the expression pattern of TSP-2 is predominantly in the fetal Leydig cell population, and the expression levels are gradually decreased after puberty due to the rapid increase of adult Leydig cell population The intermediates of adult Leydig cells first become apparent by around postnatal d 7—11 6775 The blood-testis barrier is known part a hormones and secondary sex characteristics in Clearwater function as a natural barrier to regulate the passage of various molecules into and out of the adluminal compartment of seminiferous tubules, and an immunological barrier to create a specialized environment for the differentiation and movement of developing germ cells
The appropriate regulation of androgen activity via the hypothalamic-pituitary-testis axis is necessary for development of the male phenotype, as well as for initiation and maintenance of spermatogenesis 2 , 4. Yoshinaga, K. Therapie, Copyright and , respectively, Proceedings of the National Academy of Sciences.
What is the condition called that is failure of one or both of the testes to move from the